The Pharmacogenomics of Vincristine-Induced Neuropathy
نویسندگان
چکیده
منابع مشابه
The Pharmacogenomics of Vincristine-Induced Neuropathy: On Pins and Needles.
Thevincaalkaloidvincristinehasbeenanessential componentof the treatmentofpediatric acute lymphoblastic leukemia (ALL) since combination chemotherapy first came into widespread use in the 1960s.Becausevincristinehas robust activity against both solid tumors and other malignant conditions, and because its lack of myelosuppression makes it suitable for combining at full doses with othermyelosuppre...
متن کاملvincristine-induced cranial neuropathy
how to cite this article: talebian a, goudarzi rm, mohammadzadeh m , mirzadeh as. vincristine-induced cranial neuropathy. iran j child neurol. 2014 winter; 8(1):66-68. abstract vincristine (vcr) is a vinca alkaloid that is used for treatment of many malignancies. the vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects. de...
متن کاملVincristine-induced autonomic neuropathy.
Neurological adverse effects are known to complicate vincristine treatment. In occasional reports of bowel and bladder disturbance it has not been possible to incriminate autonomic neuropathy. We report here three patients with symptoms and signs which could be ascribed to vincristine-induced autonomic neuropathy. Case Reports Case 1.-A 75-year-old man presented with recurrent Hodgkin's disease...
متن کاملVincristine induced cranial neuropathy.
Neuropathy is a well known side effect of vincristine, however cranial nerve toxicities are reported less frequently which can involve any cranial nerve in mostly bilateral pattern. As many patients have primary tumors or metastatic lesions in sites that could cause the clinician to overlook this reversible cause of neurologic dysfunction, the potential for misdiagnosis is high. Here, along wit...
متن کاملVincristine-Induced Cranial Neuropathy
Vincristine (VCR) is a vinca alkaloid that is used for treatment of many malignancies. The vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects. Described here is the case of a 2.5-year-old boy, a known case of Wilms' tumor, treated by vincristine (0.067 mg/kg/day) and dactinomycin (0.045 mg/kg/day) after surgery. Three weeks...
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ژورنال
عنوان ژورنال: JAMA Oncology
سال: 2015
ISSN: 2374-2437
DOI: 10.1001/jamaoncol.2015.1173